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FDA: 'Why You Should Not Use Ivermectin to Treat or Prevent COVID-19,' 'FDA Approves Lotion for Nonprescription Use to Treat Head Lice,' 'Ivermectin and COVID-19.'
Infectious Diseases Society of America: 'IDSA Guidelines on the Treatment and Management of Patients with COVID-19.'
World Health Organization: 'WHO advises that ivermectin only be used to treat COVID-19 within clinical trials.'
Cleveland Clinic: 'Ivermectin tablets.'
CDC: 'Strongyloidiasis Infection FAQs,' 'Onchocerciasis FAQs,' 'Selected Adverse Events Reported after COVID-19 Vaccination,' 'About Onchocerciasis,' 'Clinical Care of Scabies,' 'Filarial Worms: Treatment of Onchocerciasis.'
American Pharmacists Association: 'AMA, APhA, and ASHP Joint Statement Opposing the ordering, prescribing, or dispensing of ivermectin to prevent or treat COVID-19 outside of a clinical trial.'
American Veterinary Medical Association: 'People ingesting veterinary-use ivermectin in attempts to prevent, cure COVID-19.'
ASPCA Pro: 'What Is Ivermectin?'
Cleveland Clinic: 'Strongyloidiasis,' 'Why You Shouldn't Take Ivermectin for COVID-19.'
Dailymed: 'Ivermectin.'
DermNet: 'Ivermectin.'
Contact us to discuss your requirements of Ivermectin Suppliers. Our experienced sales team can help you identify the options that best suit your needs.
Indian Journal of Dermatology, Venereology and Leprology: 'Wonder drug for worms: A review of three decades of ivermectin use in dermatology'
Mayo Clinic: 'Ivermectin (Oral Route),' 'Ivermectin (Topical Application Route).'
MedlinePlus: 'Ivermectin.'
Proceedings of the Japan Academy. Series B, Physical and Biological Sciences: 'Ivermectin, 'Wonder drug' from Japan: the human use perspective.'
U.S. Pharmacist: 'Drug Therapy for Common Parasitic Infections Within the United States.'
University of Tennessee College of Veterinary Medicine (Joseph Smith, DVM, MPS, PhD): 'Ivermectin Use in Veterinary Medicine: What you need to know.'
Written by Joseph Smith, DVM, MPS, PhD, , Assistant Professor of Farm Animal Medicine and Pharmacology, UTCVM Department of Large Animal Clinical Sciences.
On September 1, , the American Medical Association, American Pharmacists Association, and American Society of Health-System Pharmacists released a statement on ending use of ivermectin to treat COVID-19.
Ivermectin is a member of the avermectin family of drugs that were originally developed in the s. A researcher in Japan isolated a bacteria of the genus Streptomyces near a golf course in Honshu. The bacteria was noted to produce a compound that would clear roundworm infections in mice. In , the researcher, Satoshi Ōmura, and his research partner, William C Campbell, received the Nobel Prize in Physiology or Medicine for the discovery of the avermectins.
Ivermectin functions by interfering with channels that are used to relay signals in nerve and muscle cells. The drug binds to these channels, and as a result, the channel is left in an 'open' position, which allows for an increased inhibitory effect. This leads to paralysis and the eventual death of the parasite or insect. It is important to note that while parasites and insects are more sensitive to ivermectin, the drug can act on the same receptors in mammalian cells.
Ivermectin has many uses in veterinary medicine. As an anthelmintic ('Dewormer') medication it can be used to treat multiple species of internal and external parasites. Internal parasite species that can be treated with ivermectin include gastrointestinal worms (primarily roundworms) in horses, cattle, pigs, sheep, and goats as well as lungworms in cattle and pigs. External parasites that can be treated with ivermectin in large animals include lice, mites, and grubs. In people, ivermectin is used for the treatment of river blindness (onchocerciasis) and lymphatic filariasis. It has additional uses for the treatment of lice and mite infestations in people.
There have been many recent reports of ivermectin as a possible treatment for COVID-19 in humans. It is important to keep in mind that these are preliminary studies that have not yet led to approved treatments by the US Food and Drug Administration (FDA). Currently, robust and controlled studies on the effectiveness and safety of ivermectin for COVID infections are lacking. The FDA warns, 'Using any treatment for COVID-19 that's not approved or authorized by the FDA, unless part of a clinical trial, can cause serious harm.' Ivermectin can cause toxicity in people, with adverse effects as severe as ataxia, coma, nervous system depression, and death. Using large animal formulations of ivermectin in species where it is not approved has led to overdose situations. For example: in the veterinary literature there are reports of ivermectin overdoses from the administration of the equine product to dogs, cats, ponies, and goats. At this time the FDA does not recommend the use of ivermectin to treat or prevent COVID-19. People should discuss disease treatment or prevention with their health care provider.
For more information, please visit Eprinomectin for Veterinary Use.