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However, as a registered dietitian with years of experience providing nutritional guidance, I know that not all berberine supplements are created equal. To help you find the safest berberine supplements out there, I helped the Everyday Health team and six additional nutrition experts evaluate over 15 berberine supplements. Here are the ones we recommend.
Everyday Health recommends speaking with your healthcare provider before adding any supplement to your diet to ensure that it's safe and appropriate for your health needs. It's especially important if you take prescription medications, like blood sugar-lowering drugs like metformin and insulin or blood pressure medications, because berberine can amplify their effects. People with liver conditions, who are pregnant or breastfeeding, and who are on blood thinners should also exercise caution.
Like for all supplements, the safety and effectiveness of berberine is not strictly regulated by the U.S. Food and Drug Administration, so it's important to consult a qualified healthcare expert when making your decision.
Despite the nature's Ozempic moniker, berberine does not produce the same improvements in weight as GLP-1 medications, though it may provide more modest appetite-reducing benefits, which could support you as you try to lose weight. And if this is why you're interested in berberine, Lainey Younkin, RD, LDN, owner of Lainey Younkin Nutrition in Boston, Massachusetts, recommends SoWell Balanced for its physician-designed formula and added chromium and cinnamon, two ingredients that may also have an impact on weight loss. 'Not only does it contain 900 milligrams (mg) of berberine hydrochloride (HCL), the most traditional form of berberine, but it also has 400 mg of cinnamon bark powder and 400 micrograms (mcg) of chromium as chromium picolinate,' Younkin says.
Studies show that chromium picolinate may reduce weight and body fat by helping regulate blood sugar and enhance insulin sensitivity. It may also act as an appetite suppressant. Other evidence suggests that cinnamon could reduce weight and waist circumference, and positively affect blood sugar control.Be aware that SoWell Balanced is not third-party tested, though it was formulated by an obesity medicine physician who has direct experience and expertise in weight management.
In addition, this supplement contains MCT (medium-chain triglyceride) oil, which is 'a type of fat derived from coconut oil that can promote berberine absorption,' Amidor explains. This supplement is also certified by Underwriters Laboratories, she adds, ensuring that the product has met the safety, quality, and security criteria set by this third-party organization, which sets strict standards.
Now adheres to current good manufacturing practices (CGMPs), an additional layer of protection to ensure that there are certain quality and safety procedures in the supplement production process.
'Berberine helps lower blood sugar and could be as effective as metformin, a diabetes medication, in lowering blood sugar and hemoglobin A1C in patients with type 2 diabetes, according to a study,' says Younkin. Another study showed that berberine was superior to metformin in helping reduce high cholesterol and obesity. Berberine can also help lower blood glucose.The Now brand is deeply dedicated to charity and reducing malnutrition. It is one of two founding members of Vitamin Angels, a nonprofit organization that donates essential vitamins to malnourished children worldwide.
A note on safety: 'Because berberine can lower blood sugar, check with your doctor before taking it if you are taking other blood sugar-lowering medications like metformin,' says Younkin.
While Thorne Berberine is not third-party tested (the gold standard of supplement quality), we appreciate the company's transparency into its independent research and product testing. Not all supplement brands do regular in-house testing to adhere to the highest safety, quality, and potency standards.
Thorne also shares fact sheets on each ingredient and details on its manufacturing process. Knowing where your supplement comes from can provide peace of mind.
Third-party certification requires an independent entity to test the product's manufacturing process to ensure that it complies with the highest quality, safety, and performance standards.
Liposomal berberine enhances absorption by protecting the supplement from stomach acid during digestion. In this form, the berberine is surrounded by microscopic lipid (fat) molecules called liposomes, which serve as delivery vehicles transporting berberine through the body for optimal absorption. They do this either directly when the supplement is in your mouth or by preventing its breakdown by digestive acids when it reaches the stomach.In addition to liposomal berberine, this Garden of Life supplement includes 250 million colony-forming units of Bacillus coagulans, a well-studied probiotic strain that supports the gut microbiome and effectively lowers the severity of irritable bowel syndrome symptoms, says Beale. While probiotics are generally beneficial for gut health, some people may experience gas, bloating, or constipation. However, most people report that these symptoms typically resolve within a few days.Garden of Life Liposomal Berberine also contains chromium, which can provide additional blood sugar benefits and support gut health.Note: If you want to return the product, you have to pay for shipping.
If you have polycystic ovary syndrome, you're probably looking for ways to help manage your hormonal, metabolic, and menstrual cycle fluctuations. Pure Encapsulations Berberine UltraSorb is our top pick for the best berberine for people with PCOS, as it contains a patented form of berberine called Berbevis specifically studied in those with the condition. The company also conducts ongoing research to demonstrate the effectiveness of its products.
According to Beale, 'One small study found that after taking Berbervis, women with PCOS had significant reductions in blood lipids, fat mass, body mass index, and testosterone, and better blood sugar control.' She adds that berberine led to better improvements in hormone markers like testosterone than metformin, a medication often used to treat PCOS.Research has also shown that taking 500 mg of berberine twice daily for six months helped improve irregular menstrual cycles, a common issue for people with PCOS. Taking two Pure Encapsulations capsules may be needed to provide these benefits.While Pure Encapsulations Berberine UltraSorb is not third-party tested, the formulation is developed by medical and nutrition experts, providing users with added peace of mind. The company also transparently shares its research findings on its website, where they can be easily found.
If you're seeking a berberine supplement to promote heart health, Nature's Bounty contains 1,000 mg of berberine in two capsules to support cardiovascular health. Nature's Bounty is a well-known supplement manufacturer that's been in business for 50 years, and while its products are not third-party tested, the company commits to testing its products every month to confirm that its ingredients are of the highest potency and effectiveness. 'Nature's Bounty prioritizes high-quality ingredients and conducts numerous tests throughout the manufacturing process to ensure that each supplement meets purity and potency standards,' says Younkin. She recommends splitting the dose, taking one capsule at one meal and the other with a different meal for optimal absorption.
'Berberine supplementation may benefit heart health by reducing cholesterol and triglyceride levels,' says Durston. She again refers to the meta-analysis published in showing that berberine can significantly lower triglycerides, total cholesterol, and LDL cholesterol, and may boost HDL.Nature's Bounty Berberine is also sodium-free, which is a benefit for people following low-sodium diets for heart health, and is free of many major allergens, including dairy, soy, wheat, and fish.
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NatureBell Berberine is free of the common allergens gluten, wheat, dairy, soy, tree nuts, and peanuts.
'This supplement is also third-party tested for safety and efficacy, and it's free of all major allergens, which is a huge benefit for many people,' she adds. In particular, it's free from gluten, wheat, milk, eggs, soy, peanuts, and shellfish.
We also appreciate the company's flexible return policy to provide a full refund or replacement if you're not satisfied with your purchase.
If you're on a tight budget but want to give berberine a try, these berberine capsules are a budget-friendly option, costing roughly $9 per month. 'Horbäach Berberine Ceylon Cinnamon Complex is the best berberine supplement for your wallet. In addition to berberine, this supplement contains concentrated Ceylon cinnamon, which has potential medicinal benefits, including antioxidant and anti-inflammatory properties,' says Durston.
This product contains a total of 2,000 mg of a berberine and Ceylon cinnamon complex, which can provide enhanced benefits due to cinnamon's health-promoting properties. However, the exact dose of berberine is unknown because it's part of a proprietary blend, so this product may contain more cinnamon than berberine.While Horbäach Berberine Ceylon Cinnamon Complex is not third-party tested, the company adheres to CGMPs to ensure that quality control measures are followed during the manufacturing process.
Since it's so affordable and contains berberine and cinnamon, this supplement may be worth a try if you're on a tight budget. However, it's unclear whether the berberine dose will provide meaningful benefits.
According to a U.S. News & World Report survey, Nature Made is the most recommended vitamin brand by medical experts and pharmacists. Although not third-party tested, Nature Made products are created by a team of scientists, registered dietitians, and a naturopathic doctor that routinely tracks emerging science to formulate products for maximum effectiveness.
Nature Made Better Absorption Berberine Phytosome contains 550 mg of berberine that can be taken up to two times a day for a total of 1,100 mg of berberine. This product is labeled gluten-free, but it may contain other common allergens. If you are concerned about allergies, it's best to confirm with the manufacturer before purchasing.
NutriFlair Berberine+ With Ceylon Cinnamon is our top pick for a vegan supplement due to its high dose of berberine and addition of Ceylon cinnamon for added benefits.
'NutriFlair offers a potent, organic blend that is vegan and free from GMOs [genetically modified organisms], making it an ideal choice for those seeking a vegan-friendly option. Its combination with Ceylon cinnamon supports glucose metabolism,' says Durston. GMOs are genetically engineered in some way to modify their characteristics.While NutriFlair's berberine supplement is not third-party tested, the company adheres to CGMPs and conducts in-house testing, although those results aren't posted on its website. This lack of transparency is a common concern about many supplements on the market, and we encourage customers to contact manufacturers and ask for the results for added peace of mind.
As when taking any supplement, individual results can vary, and it's important to discuss what's best for you with your doctor.
550 mg Berbervis berberine phytosome
NoVegan2 capsules dailyTo select this list of the best berberine supplements, we asked six registered dietitians for their top picks and what they look for in a quality berberine supplement.
Dose: We prioritized berberine supplements with doses shown to be clinically effective in studies or products that contain ingredients shown to enhance absorption in lower doses. 'Common doses range from 500 to 1,500 mg per day, divided into multiple doses,' says Stefani Stewart, RD, founder of Stefani Stewart Nutrition. We looked for supplements with this minimal dose or recommended multiple doses per day to meet this effective dose.
Absorption: We screened for berberine supplements with optimal absorption, such as those with a berberine phytosome complex or added MCT oil, so your body can put more of it to use.
Intended use: We narrowed down the best berberine supplements for each category based on dose, ingredients, and overall effectiveness for different uses. This included berberine combined with ingredients such as probiotics for gut health or turmeric for inflammation.
Third-party or independent lab testing: We always strive to find third-party tested supplements that meet the highest quality, potency, and safety standards. Unfortunately, most berberine supplements are not third-party certified, but we did include a few on this list.
Supplement companies may choose not to seek third-party certification, which is a lengthy process that can be costly. Many companies rely on expert validation from healthcare experts, brand loyalty, and building customer trust instead of third-party testing to validate the quality of their products.
If the products were not third-party certified, we prioritized berberine supplements that underwent extensive in-house lab testing and companies that are transparent when sharing results and follow good manufacturing practices for quality control.
When shopping for a berberine supplement, there are a few key things to look for:
Melissa Mitri is a registered dietitian-nutritionist, weight loss specialist, and expert health writer with over 18 years of experience in the health and wellness industry. She owns Melissa Mitri Nutrition, a virtual private practice helping women achieve sustainable weight loss.
Melissa is a freelance writer and editor for dietitians and wellness brands. She helps translate complicated scientific research into easy-to-understand terms for the public. Melissa has written for various publications and websites, such as HealthCanal, WellnessVerge, Nature Made, Garden of Life, the Avocado Board, and more.
Melissa believes everyone has the power to improve their health, one small habit at a time. Her approach to healthy eating focuses on what to eat more of for better health versus what to restrict or eliminate in the diet.
Melissa lives in Connecticut with her husband and two boys, where she enjoys training for half-marathons, reading, and traveling with her family.
Reyna Franco, RDN, is a New York City'based dietitian-nutritionist, certified specialist in sports dietetics, and certified personal trainer. She is a diplomate of the American College of Lifestyle Medicine and has a master's degree in nutrition and exercise physiology from Columbia University.
In her private practice, she provides medical nutrition therapy for weight management, sports nutrition, diabetes, cardiac disease, renal disease, gastrointestinal disorders, cancer, food allergies, eating disorders, and childhood nutrition. To serve her diverse patients, she demonstrates cultural sensitivity and knowledge of customary food practices. She applies the tenets of lifestyle medicine to reduce the risk of chronic disease and improve health outcomes for her patients.
Franco is also a corporate wellness consultant who conducts wellness counseling and seminars for organizations of every size. She taught sports nutrition to medical students at the Albert Einstein College of Medicine, taught life cycle nutrition and nutrition counseling to undergraduate students at LaGuardia Community College, and precepts nutrition students and interns. She created the sports nutrition rotation for the New York Distance Dietetic Internship program.
She is the chair of the American College of Lifestyle Medicine's Registered Dietitian-Nutritionist Member Interest Group. She is also the treasurer and secretary of the New York State Academy of Nutrition and Dietetics, having previously served in many other leadership roles for the organization, including as past president, awards committee chair, and grant committee chair, among others. She is active in the local Greater New York Dietetic Association and Long Island Academy of Nutrition and Dietetics, too.
Editorial Sources and Fact-CheckingEveryday Health follows strict sourcing guidelines to ensure the accuracy of its content, outlined in our editorial policy. We use only trustworthy sources, including peer-reviewed studies, board-certified medical experts, patients with lived experience, and information from top institutions.
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