Although berberine appears to be safe and causes few side effects, a person should speak with a doctor before taking it.
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Studies of berberine have indicated that it can treat several metabolic health conditions, including diabetes, obesity, and heart problems. It may also improve gut health.
Berberine has been a part of Chinese and Ayurvedic medicine for thousands of years . It works in the body in multiple ways and is able to make changes within the body's cells.
Berberine, or berberine hydrochloride, is a compound in several plants. It may help to treat diabetes, high cholesterol, and high blood pressure, among other conditions. However, side effects can include upset stomach and nausea.
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LeliaSpb/Getty ImagesThe following are conditions that berberine may help treat, according to research.
Berberine could be an effective antimicrobial agent. A study found that berberine helped inhibit the growth of Staphylococcus aureus.
S. aureus can cause many health problems, including:
Another study found that berberine has the ability to damage the DNA and protein of certain bacteria.
Inflammation is a key factor in several health conditions, including heart disease and diabetes.
Research suggests that berberine has anti-inflammatory properties, which means it could help treat diabetes and other inflammation-related health conditions.
Research has shown that berberine may work as a diabetes treatment. Studies have found that it can have positive effects on:
One literature review indicated that berberine was better than a placebo at lowering blood sugar.
The same analysis found that a combination of berberine and blood-sugar-lowering drugs is more effective than the drugs alone.
According to research, berberine shows promise as a potential diabetes treatment, especially for those who cannot take existing anti-diabetic drugs due to heart disease, liver failure, or kidney problems.
Another literature review found that berberine combined with lifestyle changes worked better to lower blood glucose than lifestyle changes alone.
Berberine appears to activate AMP-activated protein kinase, which can help regulate how the body uses blood sugar. Researchers believe this activation can help treat diabetes and related health issues, such as obesity and high cholesterol.
Another meta-analysis showed benefits in body weight and metabolic parameters, without significant elevation in liver enzymes.
However, scientists need to conduct more large, double-blind studies to fully determine berberine's safety and efficacy.
Speak with a doctor before taking berberine for diabetes. It may not be right for everyone and could interact with other medications.
High levels of low-density lipoprotein (LDL) cholesterol and triglycerides may increase the risk of heart disease and stroke.
Some evidence suggests that berberine could help lower LDL cholesterol and triglyceride levels. According to one review, studies in both animals and humans indicate that berberine has cholesterol-lowering effects.
It may help reduce LDL, or 'bad' cholesterol, and increase high-density lipoprotein, or 'good' cholesterol.
A literature review found that berberine combined with lifestyle changes works better than lifestyle changes alone in treating high cholesterol.
Researchers believe that the effects of berberine might be similar to those of drugs that reduce high cholesterol, while berberine does not cause the same side effects.
High blood pressure is a leading cause of heart disease.
A literature review found that berberine combined with a blood-pressure-lowering drug was more effective than the drug alone.
Also, results of a study of rats indicate that berberine could delay the onset of high blood pressure and, when it does develop, help reduce its severity.
Obesity is a common condition that can increase the risk of:
One review reported that people who took 750 milligrams (mg) of barberry twice a day for 3 months had a significant decrease in weight. Barberry is a plant that contains high amounts of berberine.
Also, a double-blind study found that individuals with metabolic syndrome who took 200 mg of barberry three times a day experienced decreases in their body mass index readings.
The team behind another study observed that berberine may activate brown adipose tissue. This tissue helps the body turn food into body heat, and increased activation may help treat obesity and metabolic syndrome.
Some research suggests that berberine works similarly to the drug metformin, which doctors often prescribe to treat type 2 diabetes. In fact, berberine may have the ability to change the bacteria in the gut, which could help treat both obesity and diabetes.
Polycystic ovary syndrome (PCOS) occurs when a female has high levels of certain male hormones. The syndrome is a hormonal and metabolic imbalance that can lead to infertility and other health issues.
PCOS is linked with many issues that berberine may help address. For example, a person with PCOS may also have:
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Doctors sometimes prescribe metformin, a diabetes drug, to treat PCOS. As berberine appears to have similar effects to metformin, it may also be a good treatment option for PCOS.
A systematic review found that berberine has promise as a treatment for PCOS with insulin resistance. However, the authors state that confirming these effects will require further studies.
Berberine can create changes within the molecules of cells, and this could have another potential benefit: fighting cancer.
One review found that berberine has 'clear inhibitory effects' on the following cancers:
Another study states that berberine helps treat cancer by interfering with its progression and its typical life cycle. It may also play a role in killing cancer cells.
Based on this evidence, the authors state that berberine is 'highly expected to be effective, safe, and affordable' as a cancer-fighting agent.
However, it is important to remember that researchers have only studied berberine's effects on cancer cells in a laboratory, not in people.
If berberine can help treat cancer, inflammation, diabetes, and other conditions, it may be because of a beneficial effect on gut microbiota, according to some research published in . Scientists have found links between the gut microbiome ' colonies of bacteria in the gut ' and these conditions.
Berberine has an antibacterial action that seems to remove the harmful bacteria in the gut, and thus enhance the growth of healthy bacteria.
While studies in humans and rodents have suggested this could be true, scientists caution that more research is needed to confirm how berberine affects humans and whether it is safe to use.
Berberine supplementation has gained widespread attention in the health and wellness community for its potential health benefits, particularly in supporting metabolic health including weight loss.
However, with the introduction of berberine phytosome, confusion may arise regarding the differences between these two formulations. Learn the differences between berberine and berberine phytosome in this blog to help you make informed choices about which supplement may be right for you.
Berberine Vs. Berberine Phytosome
Berberine: The Plant Compound
Berberine is a natural compound found in various plants, including goldenseal, barberry, and oregon grape. Known for its vibrant yellow colour, berberine has been used for centuries in traditional medicine for its potential health benefits, including supporting blood sugar levels, cardiovascular health, and gastrointestinal function.
Berberine Phytosome: Enhanced Absorption
Berberine phytosome is a specialised form of berberine that has been formulated for enhanced bioavailability and absorption. In this formulation, berberine is bound to phospholipids derived from sunflower oil, creating a unique molecular complex that enhances its solubility and uptake in the body.
Key Differences:
The primary difference between berberine and berberine phytosome lies in their absorption and bioavailability. While berberine on its own has relatively low absorption rates, berberine phytosome is designed to overcome this limitation, having 9.6x higher levels of absorbable berberine reaching systemic circulation, potentially enhancing possible health benefits.
Benefits of Berberine Phytosome:
Berberine phytosome offers several advantages over traditional berberine supplements. By improving absorption, berberine phytosome may require lower doses to achieve health benefits, reducing the risk of gastrointestinal side effects commonly associated with higher doses of berberine.
Additionally, the enhanced bioavailability of berberine phytosome may lead to more consistent and predictable results in supporting metabolic health and other targeted health goals.
Choosing the Right Option:
When considering whether to use berberine or berberine phytosome, it's essential to weigh the factors of absorption, dosage, and intended health goals. Individuals who prefer a natural, unaltered form of berberine may opt for traditional berberine supplements. On the other hand, those seeking enhanced absorption and potentially lower doses may find berberine phytosome to be a more suitable option.
Dosage
Berberine: At least 500 mg - mg per day.
Berberine Phytosome: Take 275 mg per day
Nutri Advanced Berberine Capsules 60
People Also Ask'
Should I take berberine or inositol for PCOS?
You can take both Inositol and berberine together, however we recommend not taking both alongside medication such as metformin until you have spoken to your doctor. Read more on our Inositol Vs Berberine for PCOS Guide.
What is the difference between Berberine HCl and Berberine Phytosome?
Berberine HCl is the hydrochloride salt form of berberine, which is commonly used in traditional berberine supplements. While Berberine HCl provides the active compound berberine, its absorption in the body may be limited due to its low solubility. Whereas, Berberine Phytosome has a higher solubility and bioavailability of berberine. Therefore, Berberine Phytosome may require lower doses to achieve similar outcomes compared to Berberine HCl.
By Rhysa Phommachanh, BA (hons) Specialist Hair and Media Make-up / Head of Digital
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